Complete genome sequences of the SARS-CoV: the BJ Group (Isolates BJ01-BJ04).
- Author:
Shengli BI
1
;
E'de QIN
;
Zuyuan XU
;
Wei LI
;
Jing WANG
;
Yongwu HU
;
Yong LIU
;
Shumin DUAN
;
Jianfei HU
;
Yujun HAN
;
Jing XU
;
Yan LI
;
Yao YI
;
Yongdong ZHOU
;
Wei LIN
;
Hong XU
;
Ruan LI
;
Zizhang ZHANG
;
Haiyan SUN
;
Jingui ZHU
;
Man YU
;
Baochang FAN
;
Qingfa WU
;
Wei LIN
;
Lin TANG
;
Baoan YANG
;
Guoqing LI
;
Wenming PENG
;
Wenjie LI
;
Tao JIANG
;
Yajun DENG
;
Bohua LIU
;
Jianping SHI
;
Yongqiang DENG
;
Wei WEI
;
Hong LIU
;
Zongzhong TONG
;
Feng ZHANG
;
Yu ZHANG
;
Cui'e WANG
;
Yuquan LI
;
Jia YE
;
Yonghua GAN
;
Jia JI
;
Xiaoyu LI
;
Xiangjun TIAN
;
Fushuang LU
;
Gang TAN
;
Ruifu YANG
;
Bin LIU
;
Siqi LIU
;
Songgang LI
;
Jun WANG
;
Jian WANG
;
Wuchun CAO
;
Jun YU
;
Xiaoping DONG
;
Huanming YANG
Author Information
- Publication Type:Journal Article
- MeSH: Genome, Viral; Haplotypes; Humans; Mutation; Open Reading Frames; Phylogeny; SARS Virus; genetics
- From: Genomics, Proteomics & Bioinformatics 2003;1(3):180-192
- CountryChina
- Language:English
- Abstract: Beijing has been one of the epicenters attacked most severely by the SARS-CoV (severe acute respiratory syndrome-associated coronavirus) since the first patient was diagnosed in one of the city's hospitals. We now report complete genome sequences of the BJ Group, including four isolates (Isolates BJ01, BJ02, BJ03, and BJ04) of the SARS-CoV. It is remarkable that all members of the BJ Group share a common haplotype, consisting of seven loci that differentiate the group from other isolates published to date. Among 42 substitutions uniquely identified from the BJ group, 32 are non-synonymous changes at the amino acid level. Rooted phylogenetic trees, proposed on the basis of haplotypes and other sequence variations of SARS-CoV isolates from Canada, USA, Singapore, and China, gave rise to different paradigms but positioned the BJ Group, together with the newly discovered GD01 (GD-Ins29) in the same clade, followed by the H-U Group (from Hong Kong to USA) and the H-T Group (from Hong Kong to Toronto), leaving the SP Group (Singapore) more distant. This result appears to suggest a possible transmission path from Guangdong to Beijing/Hong Kong, then to other countries and regions.
