Effect of large-dosage of 5alpha-reductase inhibitors on the spermatogenesis of male rats.
- Author:
Xiao-dong WANG
1
;
Yue JIA
;
Yu-gui CUI
;
Xing-hai WANG
;
Jian-sun TONG
;
Ding-zhi MA
;
Rui-fen CAI
;
Fu-song DI
Author Information
- Publication Type:Journal Article
- MeSH: 5-alpha Reductase Inhibitors; Androstadienes; pharmacology; Animals; Dose-Response Relationship, Drug; Finasteride; pharmacology; Male; Rats; Rats, Sprague-Dawley; Spermatogenesis; drug effects
- From: National Journal of Andrology 2005;11(9):652-654
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify the role of 5alpha-reductase in the spermatogenesis of male rats by studying the effect of two 5alpha-reductase inhibitors, Epristeride and Finasteride, on the spermatogenesis in male Sprague-Dawley (SD) rats.
METHODSChanges in the weight of the testis, serum testosterone and dihydrotestosterone levels, epididymal sperm count, and reproductive function were observed and analyzed after the two 5alpha-reductase inhibitors were administered to male SD rats orally.
RESULTSThe experiment showed that in comparison with control animals, both the two 5alpha-reductase inhibitors: 1. suppressed the development of the prostate and reduced the weight of the testis in the experimental groups (P < 0.05); 2. decreased the serum level of dihydrotestosterone and enhanced testosterone; 3. inhibited epididymal sperm count and productive function.
CONCLUSIONHigh dosages of the 5alpha-reductase inhibitor, Epristeride, can suppress the development of the prostate and reduce the weight of the testis, decrease dihydrotestosterone, and inhibit spermatogenesis and productive function in male rats.
