Expressions of telomerase reverse transcriptase and vascular endothelial growth factor and their correlation in prostate cancer.
- Author:
Xin LI
1
;
Na WANG
;
Yan ZHANG
;
Shun-xin ZHANG
;
Qian LIN
;
Jie TANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Humans; Immunohistochemistry; Male; Prostatic Hyperplasia; metabolism; pathology; Prostatic Neoplasms; metabolism; pathology; Rabbits; Telomerase; biosynthesis; Vascular Endothelial Growth Factor A; biosynthesis
- From: National Journal of Andrology 2005;11(10):724-730
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expressions of telomerase reverse transcriptase (TRT) and vascular endothelial growth factor (VEGF) and their correlation in prostate cancer (PCa).
METHODSTRT and VEGF expressions were assayed in 30 cases of PCa and 30 cases of benign prostatic hyperplasia (BPH) by means of immunohistochemistry (SP) combined with computer assisted image analysis.
RESULTSThe expression of TRT was detected in 19 of the 30 cases of PCa and 5 of 30 cases of BPH, and that of VEGF in 23 of the 30 PCa and 14 of the 30 BPH patients. TRT and VEGF expressions were significantly higher in cancer tissues than in BPH (P < 0.05). A significant correlation was observed between TRT and VEGF expressions (r = 0.8333, P < 0.05).
CONCLUSIONThe expression of TRT or VEGF might be a malignant phenotype in PCa. The expression of TRT is significantly correlated with that of VEGF, but the mechanisms are yet to be further studied.
