The relaxation effects of six extracts from Chinese herbs on the corpus cavernosum tissue of rabbit in vitro.
- Author:
Jun CHEN
1
;
Ji-hong LIU
;
Tao WANG
;
Shao-gang WANG
;
Chun-ping YIN
;
Heng-jun XIAO
;
Bo LIU
;
Jun YANG
;
Xiao-wen CHEN
;
Zhang-qun YE
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; pharmacology; In Vitro Techniques; Male; Muscle Contraction; drug effects; Penis; drug effects; physiology; Rabbits
- From: National Journal of Andrology 2005;11(10):793-799
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relaxants effects of six extractions from Chinese Herbs (neferine, tetrandrine, kakonein, scutellarin, ginsenoside Rgl and ginsenoside Rb1) on the corpus cavernosum tissue of rabbit in vitro.
METHODSIsolated stripes of rabbit corpus cavernosum tissue were precontracted with 10(-5) mol/L phenylephrine (PE). Relaxation in response to cumulative doses of six extracts at (10(-8) - 10(-3)) mol/L was determined.
RESULTSOn rabbit cavernosal muscle stripes precontracted with PE, neferine, tetrandrine, kakonein and scutellarin showed dose dependent relaxation. IC50 values were 4.60 x 10(-6), 3.73 x 10(-5), 8.03 x 10(-4) and 3.33 x 10(-3) mol/L, respectively. However, in the meantime, it was found that the relaxant effects of ginsenoside Rgl and ginsenoside Rbl less significant to stripes precontracted with PE. When the final concentration was 10(-3) mol/L, the relaxations were only (16.32 +/- 5.45)% and (11.21 +/- 3.10)%.
CONCLUSIONAmong the six extracts which showed relaxant effects to rabbit cavernosal muscle stripes precontracted with PE, neferine had greater functions than the other five extracts.
