Progress in the study of stem Leydig cells.
- Author:
Si-Xiao ZHANG
1
;
Qiang DONG
Author Information
1. Department of Urology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
- Publication Type:Journal Article
- MeSH:
Androgens;
deficiency;
Animals;
Cell Differentiation;
Cells, Cultured;
Humans;
Leydig Cells;
cytology;
Male;
Rats;
Stem Cells;
cytology
- From:
National Journal of Andrology
2005;11(11):803-805
- CountryChina
- Language:Chinese
-
Abstract:
Leydig cells are the primary source of testosterone. As is true for all specialized cells, Leydig cells originally arise from primitive undifferentiated stem cells, stem Leydig cells (SLCs). The huge potential of SLCs is to be used therapeutically to restore testosterone levels in males with androgen deficiency due to diverse causes. The initial paradigm for cell therapy would call for harvesting the SLCs of an androgen deficient male, amplifying these cells in vitro, inducing differentiation in vitro, and then implanting the mature Leydig cells back into the same individual.
