Influence of estradiol benzoate on fluid reabsorption capacity of rat efferent ductuli.
- Author:
Quan ZHANG
1
;
Xin-Hua ZHOU
;
Xiao-Bin ZHANG
;
Qing-Hui ZHOU
;
De-Zhi WANG
;
Xi-Chang CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Absorption; physiology; Animals; Animals, Newborn; Aquaporin 1; biosynthesis; Body Fluids; metabolism; Epithelial Cells; drug effects; metabolism; ultrastructure; Estradiol; analogs & derivatives; toxicity; Male; Rats; Rats, Sprague-Dawley; Testis; drug effects; metabolism; ultrastructure
- From: National Journal of Andrology 2005;11(11):806-809
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the influence of estradiol benzoate (E2B) on the fluid reabsorption capacity of rat efferent ductuli.
METHODSNewborn male Sprague-Dawley rats were injected subcutaneously with E2B (0.2 mg/5 g body weight), and the histological morphology of efferent ductulus, epithelial ultrastructure, and immunoexpression of AQP-1 were investigated on postnatal day 14, 21, 28, 42 and 56, respectively. Vehicle was given to the controls.
RESULTSAfter exposure to E2B, the lumina of the efferent ductuli dilated greatly (P < 0.05), and the epithelium height decreased significantly (P < 0.01), microvilli of nonciliated cells short and sparse, endocytic apparatus implicated in fluid reabsorption scarce, and with no AQP-1 expression.
CONCLUSIONHigh dosage of E2 B neonatally administrated to rats damages the fluid reabsorption capacity of efferent ductuli.
