Expression and significance of caspase-1 in benign hyperplastic prostate tissues.
- Author:
Chun-Hua DENG
1
;
Zhi-Jun ZANG
;
Xiang-Zhou SUN
;
Xiao-Hui HUANG
;
Hao WANG
;
Dong WANG
;
Sheng-Hua SU
Author Information
- Publication Type:Journal Article
- MeSH: Apoptosis; physiology; Caspase 1; biosynthesis; Humans; Immunohistochemistry; Male; Prostate; enzymology; Prostatic Hyperplasia; enzymology; pathology
- From: National Journal of Andrology 2005;11(11):810-812
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression and significance of caspase-1 in normal and hyperplastic prostate tissues.
METHODSTwenty-eight paraffin-embedded sections, including 21 benign prostatic hyperplasia (BPH) and 7 normal prostate tissue samples, were investigated immunohistochemically for caspase-1.
RESULTSThe rate of caspase-1 expression in the BPH tissues was 71.4% (15/21 ) while that in the normal prostate tissues was 100%. The expression level of caspase-1 in both epithelial cells and interstitial cells of the hyperplastic prostate tissues was obviously lower than that of the normal prostate tissues (P < 0.01). Within the BPH tissues, the expression level of caspase-1 in the epithelial cells was higher than in the interstitial cells, and the difference was statistically significant (P < 0.01).
CONCLUSIONThe expression of caspase-1 is dramatically reduced in the hyperplastic prostate tissues, which indicates that the decline of caspase-1-dependent apoptosis might be involved in the progress of benign prostatic hyperplasia.
