Study on the expression of androgen receptor in testis, epididymis and prostate of adult rats with diabetes.
- Author:
Su-huan LIU
1
;
Zhong-shan WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Diabetes Mellitus, Experimental; metabolism; Epididymis; metabolism; Male; Prostate; metabolism; RNA, Messenger; genetics; Rats; Rats, Wistar; Receptors, Androgen; biosynthesis; genetics; Testis; metabolism
- From: National Journal of Andrology 2005;11(12):891-894
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate if there is abnormal expression of androgen receptor (AR) in adult diabetic rats.
METHODSThe diabetic model rats were induced by using streptozotocin (STZ), which were divided into three groups: control (group C), diabetes (group D) and diabetes with insulin replacement group (group ID). The mRNA and protein expressions of androgen receptor in testis, epididymis and prostate were detected by Northern blot and radioimmunoassay, respectively.
RESULTSSerum testosterone levels and AR mRNA in epididymis of group D or Group ID were lower than those of group C (P <0.05) , respectively, and the protein expression of AR in testis and prostate of group D was lower than that of group C (P <0.05).
CONCLUSIONThe expression of androgen receptor decreased in testis, epididymis and prostate of diabetic rats, which weakened the biological effects of AR, and it might be one of the causes that resulted in the sexual and productive dysfunction in diabetic rats.
