Recent advances in proPSA on early detection in prostate cancer.
- Author:
Pei-yuan ZHU
1
;
Ping HONG
;
Yu-feng HUANG
Author Information
1. Laboratory of Immunohematology, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China. wjzhu@jlonline.com
- Publication Type:Journal Article
- MeSH:
Early Diagnosis;
Humans;
Male;
Prostate-Specific Antigen;
blood;
chemistry;
Prostatic Neoplasms;
diagnosis;
Protein Precursors;
blood;
chemistry;
Sensitivity and Specificity
- From:
National Journal of Andrology
2005;11(12):944-946
- CountryChina
- Language:Chinese
-
Abstract:
The precursor of prostate specific antigen (proPSA) are distinct molecular forms of free PSA in serum. proPSA is comprised of native proPSA as well as several truncated forms, in which [-2] proPSA and [-4] proPSA are more prostate cancer (PCa)-associated than [-7] proPSA and [-5] proPSA. Clinical studies have recently provided evidence that [-2] proPSA can significantly improve the detection of PCa, particularly in patients with total serum PSA values less than 4 microg/L. In this paper, the mechanism and characteristics of proPSA formation and impact of proPSA on the early detection of PCa are reviewed.
