SNP767A/T of FUS2 gene and lung cancer risk in Chinese population.

Author: Xinhua MU ¹ ; Kang SHAO ; Cuiyan ZHANG ; Zhaoli CHEN ; Junting WAN ; Kezhi ZHANG ; Ning LI ; Fang ZHOU ; Meihua XIONG ; Jie HE
Author Information

1. Laboratory of Thoracic Surgical Oncology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, P.R.China.
Publication Type:Journal Article
From: Chinese Journal of Lung Cancer 2006;9(5):409-412
CountryChina
Language:Chinese
Abstract:
BACKGROUNDFUS2 gene locating at 3p21.3 is considered a promising candidate tumor suppressor gene. The aim of this study is to examine the difference in FUS2-767A/T polymorphism site between lung cancer patients and normal controls in Chinese population.
METHODSThe genotype FUS2-767A/T was detected in 146 lung cancer patients and 113 normal controls by PCR-SSCP method. The relationship between lung cancer risk and difference in genotypes of FUS2 gene was analysed.
RESULTSFUS2-767A/T was significantly related to histological type (P=0.044), age of the patients with lung cancer (P=0.011) and vessel cancer embolus (P=0.031) in lung cancer group. There was no significant difference in distribution of FUS2 genotypes between lung cancer patients and normal controls (P=0.945).
CONCLUSIONSThe results suggest that the FUS2-767A/T polymorphism may be a susceptibility factor for lung cancer among Chinese population.