Shod-term results of audiological change of nasopharyngeal carcinoma patient after radiotherapy and chemotherapy
10.3321/j.issn:1673-0860.2008.12.008
- VernacularTitle:鼻咽癌放化疗后近期听力学改变
- Author:
Juan XIAO
1
;
Zhi-Qiang LUO
;
Da-Zhi SHI
;
Yuan-Jian HUANG
;
Yu-Fang TAN
Author Information
1. 南华大学附属第二医院
- Keywords:
Nasopharyngeal neoplasms;
Radiotherapy,computer-assisted;
Antineoplastic combined chemotherapy protocols;
Otitis media
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2008;43(12):906-909
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate short-stage results of audiological change of nasopharyngeal carcinoma patients after radiotherapy and chemotherapy treatment.Methods According to treatment modus of nasopharyngeal carcinoma,64 cases(128 ears)patients were divided to simple radiotherapy group(45 cases,90 ears)and radiotherapy with chemotherapy group(combination treatment group,19 cases,38 ears)Meanwhile,25 cases(50 ears)people took as control group,who had no obviously ear and nose disease.About two or three months after radiotherapy and chemotherapy treatment completion,three groups were detected by otoscopy,pure tone test,tympanogram and eustachian tube function,respectively.Then,hearing variation of all patients after radiotherapy and chemotherapy treatment were investigated and compared each other.At the same time,the character and level of audiological change were also analyzed.Results Eardrum character of nasopharyngeal carcinoma patients appeared change after radiotherapy.Simple radiotherapy and combination treatment groups were found having hearing impairment and eustachian tube functional disturbance.Moreover,most patients of simple radiotherapy group showed conductive deaf (24%,22/90),and combination treatment group exhibited mingle(24%,9/38)or sensorineural deafness (29%,11/38).Conclusions Recent hearing of nasopharyngeal carcinoma patients were damaged by radiotherapy and chemotherapy treatment,radiotherapy treatment induced middle ear or eustachian tube function disturbance,chemotherapy treatment had cochleotoxicity,compared with other treatment,combination treatment Was more aggravated heating impairment.
