Prognostic factors of medullary thyroid carcinoma.
- Author:
Quan ZHANG
1
;
Chuan-sheng YANG
;
Zhu-ming GUO
;
Zong-yuan ZENG
;
An-kui YANG
;
Fei-yun LAI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Carcinoma, Medullary; diagnosis; mortality; pathology; Child; Factor Analysis, Statistical; Female; Humans; Male; Middle Aged; Neoplasm Staging; Prognosis; Survival Rate; Thyroid Neoplasms; diagnosis; mortality; pathology; Young Adult
- From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2008;43(12):939-943
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate prognostic factors of medullary thyroid carcinoma.
METHODSBy using univariate analysis and multivariate analysis, the prognostic factors were investigated in 102 patients with medullary thyroid carcinoma treated at this hospital.
RESULTSOverall survival rates of 5-year, 10-year and 15-year were 87.4%, 74.6% and 54.2% respectively by Kaplan-Meier method analysis. In univariate analysis, gender, age, bilateral thyroid lobe tumors, tumor size > 4 cm, invasion of thyroid capsule, distant metastasis, and non-radical tumor resection were significant poor prognostic factors. In multivariate analysis, tumor size > 4 cm (chi(2) = 7.43, P = 0.0035), distant metastasis (chi(2) = 23.50, P = 0.0000), and non-radical tumor resection (chi(2) = 25.90, P = 0.0000) remained as independent prognostic factors.
CONCLUSIONSTumor size > 4 cm, distant metastasis, and non-radical tumor resection are the independent predictors of patients survival. Early diagnosis and early therapy can improve significantly the prognosis of medullary thyroid carcinoma.
