Prognostic factors of medullary thyroid carcinoma
10.3321/j.issn:1673-0860.2008.12.015
- VernacularTitle:甲状腺髓样癌预后影响因素分析
- Author:
Quan ZHANG
1
;
Chuan-Sheng YANG
;
Zhu-Ming GUO
;
Zong-Yuan ZENG
;
An-Kui YANG
;
Fei-Yun LAI
Author Information
1. 中山大学
- Keywords:
Thyroid neoplasm;
Carcinoma,medullary;
Prognosis;
Factor analysis,statistical
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2008;43(12):939-943
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate prognostic factors of medullary thyroid carcinoma.Methods By using univariate analysis and multivariate analysis,the prognostic factors were investigated in 102 patients with medullary thyroid carcinoma treated at this hospital.Results Overall survival rates of 5-year,10-year and 15-year were 87.4%,74.6%and 54.2%respectively by Kaplan-Meier method analysis.In univariate analysis,gender,age,bilateral thyroid lobe tumors,tumor size＞4 cm,invasion of thyroid capsule,distant metastasis,and non-radical tumor resection were significant poor prognostic factors.In multivariate analysis,tumor size＞4 cm(X2=7.43,P=0.0035),distant metastasis(X2=23.50,P=0.0000),and non-radical tumor resection(X2=25.90,P=0.0000)remained as independent pmgnostic factors.Conclusions Tumor size＞4 cm,distant metastasis,and non-radical tumor resection are the independent predictors of patients survival.Early diagnosis and early therapy can improve significantly the prognosis of medullary thyroid carcinoma.
