Treatment of allergic rhinitis with asthma by different ways of inhaling corticosteroids.
- Author:
Hua ZHANG
1
;
Xuan CHEN
;
Hui-wu WANG
;
Yang-bing XIANG
Author Information
- Publication Type:Journal Article
- MeSH: Adrenal Cortex Hormones; therapeutic use; Adult; Asthma; complications; drug therapy; Budesonide; therapeutic use; Eosinophil Cationic Protein; blood; Female; Humans; Immunoglobulin E; blood; Interleukin-5; blood; Male; Middle Aged; Rhinitis, Allergic, Perennial; complications; drug therapy; Treatment Outcome; Young Adult
- From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2009;44(1):16-20
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the therapeutical effect on allergic rhinitis with asthma by different ways of inhaling corticosteroids.
METHODSNinety patients suffering from allergic rhinitis with asthma were classified into three groups in random and treated with budesonide (BUD) by nasal spray, inhaling and nasal spray-inhaling combined administration for 12 weeks, respectively. The concentration of serum total IgE, eosinophil cationic protein (ECP) and IL-5, pulmonary functions were examined before and after treatment.
RESULTSThe improvement of symptom scores of rhinitis and asthma in three groups were significant (P < 0.05). The concentration of serum total IgE, ECP and IL-5 in three groups decreased greatly after treatment (P < 0.05). There were significant improvement in FEV1, FEV1/FVC and FEF25%-75% in inhaling group before and after treatment (P < 0.05): FEV1 from (2.04 +/- 0.45) L to (2.47 +/- 0.54) L, FEV1/FVC from (72.73 +/- 5.59)% to (75.42 +/- 5.94)% and FEF25%-75% from 1.69 +/- 0.52 to 2.06 +/- 0.77. There was also significant improvement in nasal spray-inhaling combined groups before and after treatment (P < 0.05): FEV1 from (2.32 +/- 0.56) L to (2.76 +/- 0.58) L, FEV1/FVC from (73.80 +/- 4.17)% to (76.04 +/- 4.49)% and FEF25%-75% from 2.09 +/- 0.45 to 2.34 +/- 0.64. The significant difference of FEV1 among the three treatment groups was observed (P = 0.041).
CONCLUSIONSThe symptoms of rhinitis and asthma in three groups by three ways of inhaling BUD were greatly improved, no significant difference in symptom scores and serum parameters was found.
