Relationship between aberrant FHIT transcripts and hepatocellular carcinoma.
- Author:
Yong-chun YU
1
;
Fen-yong SUN
;
Zhi LI
;
Shao-yi LU
;
Xiao-hong TENG
Author Information
- Publication Type:Journal Article
- MeSH: Acid Anhydride Hydrolases; Carcinoma, Hepatocellular; genetics; Humans; Liver Neoplasms; genetics; Mutation; Neoplasm Proteins; genetics; Polymorphism, Single-Stranded Conformational; RNA, Messenger; analysis; Reverse Transcriptase Polymerase Chain Reaction
- From: Chinese Journal of Hepatology 2003;11(9):550-551
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relationship between aberrant FHIT transcripts and hepatocellular carcinoma (HCC).
METHODSReverse transcription-polymerase chain reaction (RT-PCR) and single strand conformational polymorphism (SSCP) assays were used to analyze the transcripts and mutations of FHIT gene in 24 matched tumorous tissues and para-tumorous tissues from patients with HCC and in 4 normal liver tissues.
RESULTSAberrant FHIT transcripts were observed in 11 out of 24 (46%) tumorous tissues and in 2 (8%) of the matched para-tumorous tissues.
CONCLUSIONFHIT aberrant transcripts may play an important role in the pathogenesis of hepatocellular carcinoma.
