Serum Levels of Interleukin-8 and Tumor Necrosis Factor-alpha in Coal Workers' Pneumoconiosis: One-year Follow-up Study.
- Author:
Jong Seong LEE
1
;
Jae Hoon SHIN
;
Joung Oh LEE
;
Kyung Myung LEE
;
Ji Hong KIM
;
Byung Soon CHOI
Author Information
1. Occupational Lung Diseases Institute, COMWEL, Ansan, Korea. ljs5075@hanmail.net
- Publication Type:Original Article
- Keywords:
Anthracosis;
Interleukin-8;
Tumor necrosis factor-alpha;
Receiver operating characteristic;
Follow-up
- MeSH:
Anthracosis;
Biomarkers;
Coal;
Cytokines;
Dust;
Fibrosis;
Follow-Up Studies;
Inflammation;
Inhalation;
Interleukin-8;
Matched-Pair Analysis;
Pneumoconiosis;
ROC Curve;
Sensitivity and Specificity;
Thorax;
Tumor Necrosis Factor-alpha
- From:Safety and Health at Work
2010;1(1):69-79
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: Various cytokines induced by inhalation of coal dust may mediate inflammation and lead to tissue damage or fibrosis, such as coal workers' pneumoconiosis (CWP). METHODS: To investigate the relevance of serum cytokines in CWP, the levels of serum interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) as CWP biomarkers in 110 retired coal miners (22 controls and 88 CWP subjects) were related to cross sectional findings and 1-year progressive changes of the pneumoconiosis. Progressive changes of CWP were evaluated by paired comparison of chest radiographs. Analysis by a receiver operating characteristic curve assessed the biomarker potential of each cytokine. RESULTS: The mean serum IL-8 level was significantly higher in CWP compared to controls and IL-8 levels correlated with the degree of CWP. The median serum TNF-alpha level was significantly higher in subjects with progressive CWP compared to subjects without CWP progression. The area under the ROC curve for IL-8 (0.70) and TNF-alpha (0.72) for CWP identification and progression, respectively, indicated the biomarker potential of the two cytokines. Serum cutoff values of IL-8 and TNF-alpha were 11.63 pg/mL (sensitivity, 69%; specificity, 64%) and 4.52 pg/mL (sensitivity, 67%; specificity, 79%), respectively. CONCLUSION: The results suggest that high levels of serum IL-8 are associated with the presence of CWP and those of serum TNF-alpha are associated with the progression of CWP.
