Therapeutic effect of Tripterygium wilfordii multiglycosides on proteinuria in kidney transplant recipients.
- Author:
Yun HUANG
1
;
Tian-biao LONG
;
Feng ZHAN
;
Chu-ying PAN
;
Dao-jun CHEN
;
Shu-dian LIN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Female; Glycosides; therapeutic use; Graft Survival; immunology; Humans; Kidney Transplantation; adverse effects; immunology; Male; Middle Aged; Proteinuria; drug therapy; etiology; Tripterygium; chemistry; Young Adult
- From: Journal of Southern Medical University 2008;28(12):2269-2271
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of multiglycosides of Tripterygium wilfordii (MTW) for treatment of proteinuria in kidney transplant recipients.
METHODForty-five kidney transplant recipients with proternuria were randomized into 3 groups (n=15) and received full daily dose (1 mg/kg) MTW, half dose (0.5 mg/kg) MTW or no MTW (control) in addition to immunosuppressant therapy. The 24-hour urinary protein (24 h Upro), blood urea nitrogen (BUN), serum creatinine (Scr), dose of ciclosporin and the adverse effects of MTW were recorded.
RESULTSMTW at both the full dose and half dose significantly reduced the 24 h Upro as compared to exclusive immunosuppressant therapy (P<0.05). The therapeutic dose of ciclosporin in patients with full and half dose of MTW was significantly lower than that in the control group (P<0.05), and the patients receiving full dose MTW showed greater adverse effects than those having half dose MTW (P<0.05).
CONCLUSIONSMTW can significantly ameliorate proteinuria, reduce the therapeutic dose of ciclosporin and protect the renal function in kidney transplant recipients. While producing similar therapeutic effect to routine full dose, long-term use of half dose MTW may reduce the adverse effect associated with MTW.
