Expression of heparin-binding epidermal growth factor-like growth factor in patients with gastric carcinoma.
- Author:
Guo-rong WANG
1
;
Yan ZHENG
;
Xiang-ming CHE
;
Xiao-qiang WANG
;
Xaio-wei WANG
;
Cheng-en PAN
;
Wen-xian HE
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; metabolism; pathology; Adult; Aged; Female; Gastric Mucosa; metabolism; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; genetics; metabolism; Male; Middle Aged; RNA, Messenger; genetics; metabolism; Stomach Neoplasms; metabolism; pathology; Tumor Cells, Cultured
- From: Journal of Southern Medical University 2009;29(1):44-46
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of heparin-binding epidermal growth factor-like growth factor (HB-EGF) in patients with gastric carcinoma in different stages.
METHODSThe expressions of HB-EGF protein and mRNA in normal gastric tissues, metaplasic intestinal mucosa, early-stage gastric cancer and advanced-stage gastric cancer tissues were detected by immunohistochemistry and in situ hybridization.
RESULTSHB-EGF expression was only detected in the parietal cells of the gastric fundic glands and in gastrin cells of the pyloric glands in normal gastric tissues. Weak HB-EGF expression was detected in the epithelial cells of the gastric mucosa in intestinal metaplasic mucosa, and the expression increased in all layers of the gastric mucosa in early-stage gastric cancer. Intense HB-EGF expression was observed in advanced gastric cancer.
CONCLUSIONIncreased HB-EGF expression may be implicated in the pathogenesis and development of gastric carcinoma.
