Chorionic villus cell culture and karyotype analysis in 110 cases of early spontaneous abortion.
- Author:
Li XIONG
1
;
Jie LIU
;
Kang DENG
;
Si-ping LIU
;
Bei JIA
;
Rui-feng WU
;
Mei ZHONG
;
Rong ZENG
Author Information
- Publication Type:Journal Article
- MeSH: Abortion, Spontaneous; genetics; pathology; Adult; Cells, Cultured; Chorionic Villi; pathology; Female; Humans; Karyotyping; Pregnancy; Pregnancy Trimester, First; Trisomy; genetics
- From: Journal of Southern Medical University 2009;29(1):64-67
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the value of fetal chromosomal karyotype analysis in cases of early spontaneous abortion.
METHODSChorionic villus specimens obtained from 110 cases of early spontaneous abortion were cultured for karyotype analysis.
RESULTSOf the 110 cases, chorionic villus was successfully cultured in 103 cases (93.7%), and abnormal embryo karyotypes were identified in 52 cases (50.5%). Trisomy was the most frequent embryo karyotype abnormalities in these cases, and chromosomal aberration occurred in 29 cases (52.9%) of the first spontaneous abortion and in 23 cases (42.6%) of repeated abortions. Female fetuses accounted for 75.5% (78 cases) in the spontaneously aborted fetuses and for 67.3% (35 cases) in fetuses with chromosomal abnormalities.
CONCLUSIONEmbryo chromosomal abnormality is the most important reason of early spontaneous abortion, and karyotype analysis of the villus helps identify the causes of abortion and ensure the success of the next pregnancy.
