Expression of TBX3 mRNA and its role in the pathogenesis and metastasis of breast cancer.
- Author:
Zhong-hua CHEN
1
;
Guang-ming LÜ
;
Tian-hai JI
Author Information
- Publication Type:Journal Article
- MeSH: Breast Neoplasms; etiology; genetics; pathology; Female; Humans; Neoplasm Metastasis; genetics; RNA, Messenger; genetics; metabolism; T-Box Domain Proteins; genetics; metabolism
- From: Journal of Southern Medical University 2009;29(1):87-89
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the role of TBX3 gene in the pathogenesis of breast cancer.
METHODSThe total RNA of 51 fresh breast cancer tissues and the corresponding adjacent tissues were extracted and reverse transcribed into cDNA to detect the expression of TBX3 mRNA by real-time PCR. The correlation between TBX3 mRNA expression and the clinicopathologic parameters in relation to breast cancer metastasis was analyzed.
RESULTCompared to that in the adjacent tissues, the expression of TBX3 mRNA was markedly increased in breast cancer tissues. TBX3 mRNA expression was significantly higher in metastatic breast cancer than in non-metastatic tumors.
CONCLUSIONIncreased expression of TBX3 mRNA suggests the involvement of TBX3 in the pathogenesis and metastasis of breast cancer.
