Effect of propofol at different effect-site concentrations on approximate entropy of transient evoked otoacoustic emission signals in adults.
- Author:
Xin-jian ZHANG
1
;
Miao-ning GU
;
Jin-fang XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Anesthetics, Intravenous; pharmacology; Entropy; Female; Humans; Male; Middle Aged; Monitoring, Intraoperative; methods; Otoacoustic Emissions, Spontaneous; drug effects; Propofol; pharmacology; Young Adult
- From: Journal of Southern Medical University 2009;29(1):94-96
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of propofol at different effect-site concentrations on approximate entropy (ApEn) of transient evoked otoacoustic emission (TEOAE) signals in adults and investigate the possibility of using ApEn for monitoring anesthesia depth.
METHODSFifteen ASA class I or II patients (aged 18-49 years with normal hearing) undergoing elective surgery under general anesthesia were enrolled in this study. Anesthesia was maintained with target-controlled infusion of propofol. With the effect-site concentrations of 1, 2, 3 and 4 microg/ml, TEOAE signals were monitored and recorded before and after anesthesia. ApEn of TEOAE in 4 frequency ranges (0-2, 1-3, 2.5-4.5, and 4-6 kHz) were calculated using MATLAB software.
RESULTSThe ApEn of TEOAE in different frequency ranges showed no significant differences at the same effect-site concentration of propofol, or at different effect-site concentrations in the same frequency range (P>0.05).
CONCLUSIONAnesthesia with propofol at different effect-site concentrations does not obviously affect ApEn of TEOAE signals in adults, and ApEn can not be used as the indicator for evaluating the depth of anesthesia.
