Role of CD4+CD25+Foxp3+ regulatory T cells in type 2 diabetic nephropathy.
- Author:
Jing XU
1
;
Hong-li SU
;
Jun-hong WANG
;
Chun-hong ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; CD4 Antigens; immunology; metabolism; Case-Control Studies; Diabetes Mellitus, Type 2; immunology; Diabetic Nephropathies; immunology; Female; Flow Cytometry; Forkhead Transcription Factors; immunology; Humans; Interleukin-2 Receptor alpha Subunit; immunology; metabolism; Male; Middle Aged; T-Lymphocyte Subsets; immunology; T-Lymphocytes, Regulatory; immunology; metabolism
- From: Journal of Southern Medical University 2009;29(1):137-139
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the role of CD4+CD25+Foxp3+ regulatory T cells (Treg) in type 2 diabetic nephropathy and provide new clues for prevention and treatment of type 2 diabetic nephropathy.
METHODSFlow cytometry was used to analyze the expression rate of CD4+CD25+Foxp3+ Treg cells in 60 patients with type 2 diabetes and 15 normal subjects.
RESULTSNo significant difference was found in the expression rate of CD4+CD25+Foxp3+ Treg cells between the control group and the type 2 diabetic patients. In the type 2 diabetic patients with microalbuminuria and macroalbuminuria, the expression of CD4+CD25+Foxp3+ Treg cells was significantly lowered in comparison with that in the control group (P<0.05), and patients with macroalbuminuria showed significantly lower expression of CD4+CD25+Foxp3+ Treg cells than the microalbuminuric patinets (P<0.05). Significant inverse correlations were noted between the disease course and the expression of CD4+CD25+Foxp3+ Treg cells and between the urinary albumin excretion rate (UAER) and the expression of CD4+CD25+Foxp3+ Treg cells.
CONCLUSIONCD4+CD25+Foxp3+ Treg cells may play a role in the occurrence and development of type 2 diabetic nephropathy.
