Expression of Beclin1 in primary hepatocellular carcinoma.
- Author:
Kai-fu KANG
1
;
Xiao-wei WANG
;
Xiao-wu CHEN
;
Guang-ming TAN
;
Zi-jing KANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Apoptosis Regulatory Proteins; genetics; metabolism; Beclin-1; Carcinoma, Hepatocellular; metabolism; pathology; Female; Humans; Immunohistochemistry; Liver Neoplasms; metabolism; pathology; Male; Membrane Proteins; genetics; metabolism; Middle Aged
- From: Journal of Southern Medical University 2009;29(1):151-153
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect Beclin1 expression and explore its clinical significance in primary hepatocellular carcinoma (HCC).
METHODSBeclin1 expressions in 10 normal hepatic tissues, 30 hepatitis liver, 30 cirrhotic liver and 50 HCC tissues were detected by immunohistochemical staining.
RESULTSThe positivity rates of Beclin1 expression in the HCC, cirrhotic liver, hepatitis liver and normal liver tissues were 78.00% (39/50), 26.67% (8/30), 53.33% (16/30), and 10.00% (1/10), respectively, showing significant differences between them (chi(2)=28.31, P<0.05). Beclin1 expression was significantly higher in HCC tissues than in the cirrhotic, hepatitis and normal liver tissues (chi(2)=20.39, 5.31, and 14.41, respectively, P<0.05), and hepatitis tissues showed significantly higher Beclin1 expression than hepatic cirrhosis tissues and normal hepatic tissues (chi(2)=4.44 and 4.12, respectively, P<0.05).
CONCLUSIONThe abnormal expression of Beclin1 is closely associated with the pathogenesis and development of primary hepatocellular carcinoma, and may play an important role in this process.
