Survivin and COX-2 expressions in giant cell tumor of bone and their relation to the prognosis.
- Author:
Si-min LUO
1
;
Ren-de LIU
;
Wen-rui LI
;
Jing-hui HOU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Bone Neoplasms; metabolism; pathology; Cyclooxygenase 2; genetics; metabolism; Female; Giant Cell Tumor of Bone; metabolism; pathology; Humans; Inhibitor of Apoptosis Proteins; Male; Microtubule-Associated Proteins; genetics; metabolism; Middle Aged; Prognosis; Young Adult
- From: Journal of Southern Medical University 2009;29(1):156-159
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of survivin and COX-2 in giant cell tumor of bone (GCT) and explore the prognostic factors for GCT.
METHODSThe expressions of survivin and COX-2 in 39 GCT tissues of three Jaffe grades and 4 normal bone tissues were detected by immunohistochemical staining, and the data were analyzed in relation to the clinicopathological features of the patients.
RESULTSThe expressions of survivin and COX-2 were significantly higher in the GCT tissues than in normal bone tissues (P<0.01). A positive correlation was found between survivin and COX-2 expressions and the pathological grade (P<0.01), but their expressions were not correlated to the patients' gender, age or surgical approaches (P>0.05). An obviously lowered recurrence rate was observed in patients with resection of the bone segment compromised by the tumor and subsequent bone grafting. Survivin and COX-2 were not independent risk factors of the prognosis of GCT.
CONCLUSIONSurvivin and COX-2 expressions may participate in the pathogenesis and development of GCT, but is not indicative of the prognosis.
