Retrospective Case Series of Aripiprazole Augmentation in Pervasive Developmental Disorders.
- Author:
Yeni KIM
1
;
Soo Churl CHO
;
Min Sup SHIN
;
Jae Won KIM
;
Seung Hee LEE
;
Boong Nyun KIM
Author Information
1. Division of Child & Adolescent Psychiatry, Department of Psychiatry and Institute of Human Behavioral Medicine, Seoul National University College of Medicine, Seoul, Korea. kbn1@snu.ac.kr
- Publication Type:Brief Communication
- Keywords:
Aripiprazole;
Augmentation;
Autism;
Pervasive developmental disorder
- MeSH:
Autistic Disorder;
Child;
Humans;
Obsessive Behavior;
Piperazines;
Quinolones;
Retrospective Studies;
Self-Injurious Behavior;
Sleep Initiation and Maintenance Disorders;
Tics;
Aripiprazole
- From:Psychiatry Investigation
2010;7(3):220-223
- CountryRepublic of Korea
- Language:English
-
Abstract:
Due to co-morbidities and treatment resistant nature of pervasive developmental disorder (PDD), diverse combinations of regimens have been tried. This retrospective study aimed to explore adjunctive use of aripiprazole in children with PDD. Changes in illness severity were measured by Clinical Global Impression of Severity (CGI-S) and Clinical Global Impression of Improvement (CGI-I) in 14 aripiprazole-treated patients with PDD. Improvement of illness severity was observed after aripiprazole add-on (5.8+/-0.8 to 4.9+/-1.0, Z=-2.75, p=0.001). Mean dosage was 7.7 mg/day [standard deviation (SD) 3.3, range 5-15]. A higher mean dosage was observed in group with improvement in symptoms (t=-2.33, df =12, p=0.004). The target symptoms most effectively improved after using aripiprazole were positive psychotic symptoms (mean CGI-I: 2.0+/-1.4, 3 responders/4 patients, 75% response) followed by aggressive behavior (2.5+/-1.7, 3/4, 75%), self-injurious behavior (2.0+/-1.0, 2/3, 67%), stereotypic behavior (2.7+/-1.2, 2/3, 67%), tic (2.8+/-1.0, 2/4, 50%), irritability (3.5+/-2.1, 1/2, 50%), obsessive behavior (2.5+/-2.1, 1/3, 33%), hyperactivity (3.4+/-1.6, 3/7, 43%) and mood fluctuation (3, 0/1, no response). Five patients (35%) discontinued aripiprazole due to treatment-emergent adverse effects (akathisia, insomnia, withdrawal). The results of this study suggest that aripiprazole augmentation may be used safely in maladaptive behaviors of some populations of PDD. However, future studies are required to con-firm these preliminary findings.
