Correlation between T lymphoma invasion and metastasis 1 expression and epithelial-mesenchymal transition in human colorectal carcinomas.
- Author:
Jie HU
1
;
Ya-dong WANG
;
Yu-fa LI
;
Ya-juan WANG
;
Hui-xia HAN
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; metabolism; pathology; Adult; Aged; Aged, 80 and over; Cadherins; genetics; metabolism; Cell Movement; physiology; Cell Transdifferentiation; genetics; physiology; Colorectal Neoplasms; metabolism; pathology; Epithelial Cells; pathology; Female; Guanine Nucleotide Exchange Factors; genetics; metabolism; Humans; Keratins; genetics; metabolism; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; T-Lymphoma Invasion and Metastasis-inducing Protein 1; Young Adult
- From: Journal of Southern Medical University 2009;29(2):232-235
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between T lymphoma invasion and metastasis 1 (Tiam1) and epithelial-mesenchymal transition (EMT) in human colorectal carcinomas.
METHODSTiam1, E-cadherin, CK, and vimentin expressions in normal colorectal epithelium, colorectal carcinomas (CRC) and CRC with lymphatic metastasis were determined by immunohistochemistry using a two-step method.
RESULTSTiam1 expression was significantly higher in CRC than in normal colorectal epithelium (P<0.01) in close correlation to the degree of tumor differentiation (P<0.05). Higher Tiam1 expression was detected in CRC with lymphatic metastasis than in primary CRC (P<0.05). The expressions of E-cadherin and CK in CRC tissues were significantly lowered in comparison with those in normal colorectal epithelium (P<0.01), showing a correlation to tumor differentiation (P<0.01) but not to lymphatic metastasis. Vimentin was significantly overexpressed in CRC (P<0.01) and correlated to tumor differentiation (P<0.01) but not to lymphatic metastasis. Tiam1 expression was inversely correlated to E-cadherin and CK, but positively to vimentin.
CONCLUSIONTiam1 is related to the metastasis of colorectal carcinoma, and may induce EMT to promote CRC metastasis.
