Therapeutic effect of intravenous high-dose vitamin C on implanted hepatoma in rats.
- Author:
Lin-ji PENG
1
;
Da-xiang LU
;
Ren-bin QI
;
Tao ZHANG
;
Zhen WANG
;
Yong SUN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis; drug effects; Ascorbic Acid; administration & dosage; Injections, Intravenous; Liver Neoplasms, Experimental; drug therapy; pathology; Male; Necrosis; Neoplasm Transplantation; Rats; Rats, Sprague-Dawley; Rats, Wistar
- From: Journal of Southern Medical University 2009;29(2):264-266
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the therapeutic effect of intravenous high-dose vitamin C on implanted hepatoma in rats.
METHODSThe rats bearing implanted Walker-256 hepatoma were treated with high-dose vitamin C at 2.83 and 5.65 g/kg intravenously, and the general condition, liver functions (A/G, ALT, AST, GGT), tumor volume, and tumor growth of the rats were evaluated.
RESULTSThe A/G of the rats treated with 2.83 g/kg vitamin C was significantly higher, but the ALT and GCT were significantly lower than those of the model rats (P<0.05 or 0.01). The ALT level in rats with 5.65 g/kg vitamin C treatment was significantly lower than that of the model rats (P<0.05). The tumor necrosis rate was significantly higher in rats with 2.83 g/kg vitamin C treatment than in the model rats (P<0.05).
CONCLUSIONIntravenous administration of 2.83 g/kg vitamin C can promote the necrosis and apoptosis of hepatoma Walker256 cells in rats and protect the liver function of the tumor-bearing rats.
