Dose-effect relationship between premature chromosome and irradiation dose.
- Author:
Bo JIANG
1
;
Qiang LIU
;
En-Hai JIANG
;
Zhi-Wei XING
;
Xin-Ran ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Cell Line; Chromosome Aberrations; radiation effects; Chromosome Banding; Chromosomes; radiation effects; Dose-Response Relationship, Radiation; Female; Gamma Rays; adverse effects; Humans; Lymphocytes; radiation effects; Male; Oxazoles; pharmacology; Young Adult
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2007;25(12):714-717
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the dose-effect relationship between premature chromosome condensation induced by Calyculin A and irradiation dose.
METHODSThe human peripheral blood was irradiated by (137)Cs gamma radial. The irradiation dose included 0, 0.5, 1.0, 2.0, 3.0, 4.0, 5.0 Gy. The premature chromosome condensation induced by Calyculin A was observed, and dyed by centromeric banding.
RESULTSThere was the quadratic relation between the total aberration, fragment, dicentric+centric ring (dic+r) ration and irradiation dose.
CONCLUSIONPremature chromosome condensation induced by Calyculin A can be used as a biodosimetry.
