Wilms' Tumor with Long-delayed Recurrence: 25 Years after Initial Treatment.
10.4111/kju.2012.53.4.288
- Author:
So Young LEE
1
;
Kyu Rae KIM
;
Jung Yeol PARK
;
Jae Y RO
Author Information
1. Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. soyounglee99@gmail.com
- Publication Type:Case Report
- Keywords:
Drug therapy;
Late recurrence;
Therapeutics;
Wilms tumor
- MeSH:
Abdominal Pain;
Adult;
Female;
Humans;
Mitosis;
Necrosis;
Nephrectomy;
Recurrence;
Wilms Tumor
- From:Korean Journal of Urology
2012;53(4):288-292
- CountryRepublic of Korea
- Language:English
-
Abstract:
Wilms' tumor is one of the most frequent malignant neoplasms in childhood. Advances in treatment modalities such as the combination of chemoradiation therapy with surgery have enhanced overall survival. However, recurrence of Wilms' tumor is still a problem. In this case, a 28-year-old female had experienced intermittent abdominal pain, and the computed tomography scan showed a huge pelvic mass. The patient had a history of radical nephrectomy for Wilms' tumor with concurrent chemotherapy at the age of three. The pelvic mass was resected in February 2010 and was confirmed to be a recurrent Wilms' tumor. The recurrent tumor showed a classic triphasic Wilms' tumor growth pattern with frequent mitoses and tumor necrosis. Our case is an extraordinary case of a long-delayed recurrent Wilms' tumor after 25 years, which is the longest disease-free interval ever reported. The possible effects of chemotherapy as well as some other mechanisms of this late relapse are discussed.
