Multidrug-resistant Tuberculosis Burden among the New Tuberculosis Patients in Zhejiang Province: An Observational Study, 2009-2013.

Ying Peng; Song-hua Chen; Le Zhang; Bin Chen; Ming-wu Zhang; Tie-niu HE; Fei Wang; Cheng-liang Chai; Lin Zhou; Yu Zhang; Xiao-meng Wang; Zhongwei Jia

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Multidrug-resistant Tuberculosis Burden among the New Tuberculosis Patients in Zhejiang Province: An Observational Study, 2009-2013.

Author: Ying PENG ¹ ; Song-Hua CHEN ¹ ; Le ZHANG ² ; Bin CHEN ¹ ; Ming-Wu ZHANG ¹ ; Tie-Niu HE ¹ ; Fei WANG ¹ ; Cheng-Liang CHAI ¹ ; Lin ZHOU ¹ ; Yu ZHANG ¹ ; Xiao-Meng WANG ¹ ; Zhongwei JIA ³
Author Information

1. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, China.
2. National Institute of Drug Dependence
3. National Institute of Drug Dependence, Peking University, Beijing 100191, China.
Publication Type:Journal Article
From: Chinese Medical Journal 2017;130(17):2021-2026
CountryChina
Language:English
Abstract:
BACKGROUNDScreening on multidrug-resistant tuberculosis (MDR-TB) has been limited to the serious TB subpopulations excluding the new TB patients. This study aimed to examine MDR-TB burden among the new TB patients.
METHODSWe conducted a study in Zhejiang Province during 2009-2013 to screen for MDR-TB patients among the low MDR-TB risk patients and five subpopulations of high MDR-TB risk patients. The number, prevalence, and trend of MDR-TB were compared while the logistic regression model was used to examine risk factors related to MDR-TB.
RESULTSA total of 200 and 791 MDR-TB cases were, respectively, identified from the 9830 new TB cases and 2372 high-risk suspects who took MDR-TB screening from 2009 to 2013. The MDR-TB rates went down in both of the new TB patients and five MDR-TB high-risk groups over the study time, but the percentage of MDR-TB patients identified from the new TB patients in all diagnosed MDR-TB cases kept stable from 28.3% in 2011 to 27.0% in 2012 to 26.0% in 2013.
CONCLUSIONSThe study indicated that MDR-TB burden among new TB patients was high, thus screening for MDR-TB among the new TB patients should be recommended in China as well as in the similar situation worldwide.