Effect and mechanism of traditional Chinese medicine and their active constituents in postmenopausal osteoporosis.
- Author:
Piwen ZHAO
1
;
Jianzhao NIU
;
Yue-Wei Lee DAVID
;
Jifeng WANG
;
Yanling SUN
;
Yadong LI
Author Information
1. School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, China.
- Publication Type:Journal Article
- MeSH:
Chemistry, Pharmaceutical;
Drugs, Chinese Herbal;
chemistry;
pharmacology;
therapeutic use;
Humans;
Medicine, Chinese Traditional;
methods;
Osteoporosis, Postmenopausal;
drug therapy;
Receptors, Estrogen;
metabolism
- From:
China Journal of Chinese Materia Medica
2012;37(12):1693-1699
- CountryChina
- Language:Chinese
-
Abstract:
Postmenopausal osteoporosis is one of the commonest systemic bone metabolism diseases among menopausal women, mainly caused by lowering internal estrogen. Although Hormone Replacement Therapy (HRT) is an effective method in clinical practice for years, it shows side-effect in increasing gynecological carcinoma. It has already been proved by clinical tests that multiple traditional Chinese medicine formulas and their monomer ingredients and phytoestrogen-like active constituents contained in traditional Chinese medicines are effective on treating osteoporosis with relatively less side-effects comparing with HRT. They show protective and therapeutic effects by acting on estrogen receptors of targeted tissues and targeted cells and then affecting expressions of bone metabolism-related regulatory proteins and factors in downstream signal conduct paths. Recent studies on estrogen related receptor (ERR) provide new possibilities and pathways for mechanism of traditional Chinese medicine and their active constituents in osteoporosis.
