Regulatory mechanism of p38MAPK signaling pathway on renal tissue inflammation in chronic kidney disease and interventional effect of traditional Chinese medicine.
- Author:
Qing ZHAO
1
;
Yigang WAN
;
Chaojun WANG
;
Qingxue WEI
;
Haoli CHEN
;
Xianjie MENG
;
Jian YAO
Author Information
1. Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, China. qq443922489@126.com
- Publication Type:Journal Article
- MeSH:
Animals;
Chronic Disease;
Humans;
Inflammation;
drug therapy;
pathology;
Kidney Diseases;
drug therapy;
pathology;
Medicine, Chinese Traditional;
methods;
Signal Transduction;
drug effects;
p38 Mitogen-Activated Protein Kinases;
metabolism
- From:
China Journal of Chinese Materia Medica
2012;37(12):1700-1704
- CountryChina
- Language:Chinese
-
Abstract:
The inflammatory reaction of renal tissues and its relevant tissue damages (such as glomerulosclerosis and renal interstitial fibrosis) are important factors for the development of chronic kidney diseases (CKD) to end-state renal diseases. Of them, p38 mitogen-activated protein kinase (MAPK) signaling pathway plays an important role in regulating expression and bioactivity of multiple nuclear transcription factors, impacting synthesis of downstream inflammatory mediators and activating inflammatory cells. Some monomer traditional Chinese medicines and their extracts (such as emodin and berberine) and some traditional Chinese medicine compound prescriptions (such as Yishen Huoxue decoction) can affect inflammatory reaction of renal tissues by regulating p38MAPK signaling pathway, thas improving reduce glomerulus and renal interstitial inflammatory injury.
