Tissue distribution of ginsenoside Rg1 before and after modification by PEG.
- Author:
Mei LIU
1
;
Li WANG
;
Kaili HU
;
Jianfang FENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Calibration; Ginsenosides; chemistry; pharmacokinetics; Mice; Polyethylene Glycols; chemistry; Tissue Distribution
- From: China Journal of Chinese Materia Medica 2012;37(12):1747-1750
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate targeted distribution of ginsenoside Rg1 in mice tissues before and after modification by the PEG.
METHODSD mice were randomly divided into two groups and given Rg1 and PEG-Rg1 by intravenous injection respectively. Their samples of blood and organ tissues were taken at different time points. The content of Rg1 in samples were determined by UPLC and used as indicator to observe the targeted distribution of Rg1 in mice tissues.
RESULTThe AUC of ginsenoside Rg1 in tissues of the Rg1 group were in the order of liver, kidney, lung, heart and spleen, with the liver targeting coefficient was of 2.01. While the AUC of ginsenoside Rg1 in tissues of the PEG-modified group were in the order of the kidney, liver, lung, heart, spleen, with the liver targeting coefficient was of 9.21.
CONCLUSIONPEG modified Rg1 can increase Rg1's targeting selectivity to the liver, kidney and lung in mice.
