Pharmacokinetics of Danshen multi-component osmotic pump tablets in Beagle dogs.
- Author:
Lin ZHOU
1
;
Xianying LIU
;
Jinfeng ZHENG
;
Qing WU
;
Shouying DU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Dogs; Drugs, Chinese Herbal; pharmacokinetics; Male; Osmosis; Salvia miltiorrhiza; chemistry; Tablets; Time Factors
- From: China Journal of Chinese Materia Medica 2012;37(12):1761-1764
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the variation in plasma concentration after oral administration of Danshen multi-component osmotic pump tablets in Beagle dogs with conventional Danshen tablets as the control preparation, in order to assess the sustained release of Danshen multi-component osmotic pump tablets.
METHODHPLC was adopted for determination, with Shimadzu's ODS-SP column (4.6 mm x 150 mm, 5 microm), flow rate of 1 mL x min(-1), and column temperature of 30 degrees C. Protein in plasma samples of tanshinone II(A) and salvianolic acid B was removed by ethyl acetate extract and acetone precipitation method respectively. Their pharmacokinetic parameters were calculated based on determination results.
RESULTThe methodology study on the two constituents with different polarity showed conformity to the requirements. Compared with conventional Danshen tablets, Danshen multi-component osmotic pump tablets showed decrease in Cmax and extension in Tmax after oral administration in Beagle dogs.
CONCLUSIONDanshen multi-component osmotic pump tablet has a good sustained-release effect compared with conventional Danshen tablets.
