Study on intestinal absorption of mollugin and purpurin in rats.
- Author:
Kan WANG
1
;
Xing CHEN
;
Mingqiu SHAN
;
Anwei DING
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anthraquinones; metabolism; Female; Intestinal Absorption; Male; Pyrans; metabolism; Rats; Rats, Sprague-Dawley; Reproducibility of Results
- From: China Journal of Chinese Materia Medica 2012;37(12):1855-1858
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the absorption kinetic characteristics of mollugin and purpurin in each intestinal segment of rats.
METHODThe in situ single-way perfusion rat model was established to study absorption characteristics of mollugin and purpurin in each intestinal segment of rats. The volume of recirculation fluid was regulated by phenol red.
RESULTDifferent quality concentrations (12.33, 24.66, 49.32 mg x L(-1)) of mollugin and (8.455, 16.91, 33.82 mg x L(-1)) purpurin showed a concentration gradient of absorption dose in each intestinal segment, with the osmotic coefficient increasing to more than 0.2 x 10(-4) cm x s(-1). In the same concentration, mollugin and purpurin showed an identical trend of P(eff) in each intestinal segment in the order of colon > duodenum > ileum > jejunum, with a significant difference (P < 0.05).
CONCLUSIONMollugin and purpurin are highly permeable in rat intestinal segments, with absorption in each segment, while the specific absorption existed in the colon segment.
