Experimental study on anaphylactoid reactions of guinea pig induced by danshen injection and its components.
- Author:
Weifeng YANG
1
;
Xuezhao YU
;
Ping HE
;
Wei HAO
;
Yikui LI
Author Information
- Publication Type:Journal Article
- MeSH: Anaphylaxis; chemically induced; Animals; Drugs, Chinese Herbal; toxicity; Female; Guinea Pigs; Injections; methods; Male; Phenanthrolines; toxicity; Salvia miltiorrhiza; chemistry; toxicity
- From: China Journal of Chinese Materia Medica 2012;37(13):1894-1897
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the anaphylactoid effect of Danshen injection and its components on guinea pig.
METHODApplying active systemic anaphylaxis (ASA) tests, the corresponding experimental injections were administrated to guinea pigs to sensitized, and allergen with double doses was injected to stimulate in the 11 days after the last sensitized. The anaphylaxis situation of guinea pigs was observed.
RESULTDanshen injection and its components are suspicion on guinea pigs, while negative reaction was observed on guinea pigs which injected by the liquid excipients of Danshen injection.
CONCLUSIONDanshen injection using the ultrafiltration method still have some antigenic impurities which cannot be removed completely, and this may be one of the reasons for anaphylactic reaction.
