Relationship between specific immunocyte and pseudoanaphylactoid reactions induced by Shuanghuanglian injection.
- Author:
Yan YI
1
;
Aihua LIANG
;
Chunying LI
;
Yong ZHAO
;
Yunting WANG
;
Guiqin LI
Author Information
- Publication Type:Journal Article
- MeSH: Anaphylaxis; chemically induced; immunology; Animals; Drugs, Chinese Herbal; toxicity; Immune System; drug effects; Injections; methods; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mice, SCID
- From: China Journal of Chinese Materia Medica 2012;37(13):1898-1900
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between specific immunocyte and pseudoanaphylactoid reactions (PR) induced by Shuanghuanglian injection (SHLI).
METHODICR mice, SCID mice and BALB/C athymic mouse were divided into different test groups, the mice were intravenously injected with solutions of different concentration of SHLI, positive control Compound 48/80 and normal sodium. All test substances were mixed with 0. 4% Evans blue. The reaction and vascular permeability of the ears were observed and measured 30 min after SHLI injected.
RESULTSHLI of 300, 600 mg x kg(-1) caused obvious vascular hyperpermeability in ICR mice, but the same dose of SHLI didn't cause vascular hyperpermeability in SCID mice and BALB/C athymic mouse.
CONCLUSIONSHLI in equivalent and 2 times the clinical dose can cause PR in ICR mice, but the same dose of SHLI can't cause PR in SCID mice and BALB/C athymic mouse, so specific immunocyte maybe take part in the SHLI-induced PR.
