A new C-28 nortriterpenoid from fruits of Leonurus japonicus.

Author: Yuqing ZHENG ¹ ; He YAN ; Jing HAN ; Ninghua TAN
Author Information

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Publication Type:Journal Article
MeSH: Chromatography, High Pressure Liquid; Fruit; chemistry; Leonurus; chemistry; Triterpenes; chemistry; isolation & purification
From: China Journal of Chinese Materia Medica 2012;37(14):2088-2091
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo study the chemical constituents from the fruits of Leonurus japonicus.
METHODThe compounds were extracted by 70% methanol, then isolated and purified by column chromatography on silica gel, RP-18, Sephedax LH-20 and HPLC. Their structures were determined on the basis of spectroscopic data and physicochemical property.
RESULTTwo 28-noroleanane-derived spirocyclic triterpenoids including a new acylated nortriterpenoid were isolated and identified as (17R)-19(18 --> 17)-abeo-2alpha,18beta,23-trihydroxy-3beta-E-feruloyoxy-28-norolean-12-ene (1) and phlomistetraol B (2).
CONCLUSIONCompound 1 is a new compound,named as leonujaponin A. Both compounds 1-2 are isolated for the first time from Leonurus plants.