Effect of icariin on learning and memory abilities and activity of cholinergic system of senescence-accelerated mice SAMP10.
- Author:
Linna GAO
1
;
Qianqi TANG
;
Xiaoli HE
;
Minggang BI
Author Information
- Publication Type:Journal Article
- MeSH: Acetylcholine; analysis; Alzheimer Disease; drug therapy; Animals; Cerebral Cortex; chemistry; Disease Models, Animal; Drugs, Chinese Herbal; pharmacology; Female; Flavonoids; pharmacology; Learning; drug effects; Male; Maze Learning; drug effects; Memory; drug effects; Mice; Parasympathetic Nervous System; drug effects
- From: China Journal of Chinese Materia Medica 2012;37(14):2117-2121
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of icariin (ICA) on learning and memory abilities and cholinergic system in senescence-accelerated mice SAMP10.
METHODThe 8-month-old senescence-accelerated mice were randomly divided into the model SAMP10 group and the positive Donepezil group (1 mg x kg(-1)) and ICA groups (50, 100, 200 mg x kg(-1)), with 12 mice in each group. Another 12 8-month-old mice SAMR1 were selected as the normal control group. After 30 days of oral administration, Morris water maze, SMG-2 water maze and experimental platform were used to test the effects of ICA on learning and memory abilities of SAMP10 groups. By colorimetric determination of AChE activity in the cortex, enzyme-linked immunosorbent assay detection of ACh, ChAT, MCBC of the cerebral cortex, the effect of ICA on the cholinergic system of SAMP10 was observed.
RESULTICA could improve the abilities of space exploration and positioning navigation of SAMP10, shorten the latency in SMG-2 water maze, enhance their jumping ability in response to the passive test, and increase levels of ACh, ChAT, MCBC in the cerebral cortex of SAMP10. But its active effect on AChE in SAMP10 cortex was not obvious.
CONCLUSIONDifferent doses of icariin can improve learning and memory abilities of SAMP10 to varying degrees, which may be related to its effect on the cholinergic system.
