Effects of mild hypothermia on patients with lower intracranial pressure following severe brain injury.
- Author:
Wei-ping WANG
1
;
Hai-jun REN
;
Jing-yang CHI
;
Fu-lin XU
;
Yong QUAN
Author Information
- Publication Type:Clinical Trial
- MeSH: Analysis of Variance; Chi-Square Distribution; Craniocerebral Trauma; cerebrospinal fluid; therapy; Enzyme-Linked Immunosorbent Assay; Female; Glasgow Coma Scale; Humans; Hypothermia, Induced; Intracranial Pressure; Male; Treatment Outcome
- From: Chinese Journal of Traumatology 2005;8(1):54-56
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo study the effects of mild hypothermia therapy on severe brain-injured patients whose intracranial pressure (ICP) could be maintained below 25 mm Hg.
METHODSForty severe brain-injured patients with ICP below 25 mm Hg were divided randomly into one treatment group (n=20, mild hypothermia therapy) and one control group (n=20, normothermia therapy) to observe the changes of the concentration of excitatory amino acids (glutamate and glycine) and cytokines (interleukin-1beta and interleukin-6).
RESULTSThere were no significant differences in the daily changes of the concentration of excitatory amino acid and cytokines between two groups. The outcome of two groups had no significant differences.
CONCLUSIONSMild hypothermia has no additional beneficial effects on severe brain-injured patients compared with normothermia therapy if ICP can be maintained below 25 mm Hg by using conventional therapy.
