Changes of osteocalcin and IGF-I during bone lengthening.
- Author:
Bing WANG
1
;
Yi-yun LIU
;
Jie-bai ZHENG
;
Shi-xiang YUAN
;
Guo-xun CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Analysis of Variance; Animals; Biomarkers; analysis; Bone Lengthening; methods; Disease Models, Animal; Dogs; Female; Insulin-Like Growth Factor I; analysis; metabolism; Male; Osteocalcin; analysis; metabolism; Probability; Radioimmunoassay; Random Allocation; Sensitivity and Specificity; Statistics, Nonparametric; Tibia; surgery
- From: Chinese Journal of Traumatology 2005;8(3):151-155
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo examine the changes of osteocalcin and insulin-like growth factor I (IGF-I) during bone lengthening, and to clarify the mechanism of bone healing.
METHODSThirty-two shepherd dogs were divided into five groups randomly. Their tibiae were lengthened by Ilvzarov's external fixator at the rate of 1 mm/day. The lengthening area was the experimental side and the opposite side was the control. Samples were obtained on the 2nd, 4th, 6th, 8th, 12th weekend respectively. The samples were defatted, dried, powdered, centrifuged and measured by radioimmunoassay.
RESULTSThe osteocalcin concentration increased at the subsequent periods, but it was significantly lower in the experimental side than that of the control side, P<0.05 and the IGF-I concentration was not significantly lowered.
CONCLUSIONSDifferent noncollagenous bone growth factors may be different at different stage.
