Pyrroloquinoline quinone enhances regeneration of transected sciatic nerve in rats.
- Author:
Hao-huan LI
1
;
Shi-qing LIU
;
Hao PENG
;
Nu ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Male; Nerve Regeneration; drug effects; PQQ Cofactor; pharmacology; Rats; Rats, Sprague-Dawley; Sciatic Nerve; injuries; pathology; physiology
- From: Chinese Journal of Traumatology 2005;8(4):225-229
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the effect of pyrroloquinoline quinone (PQQ) on nerve regeneration of transected sciatic nerve in animal models.
METHODSForty SD rats weighing 220-240 g were randomized into a PQQ group (n = 20) and a control group (n = 20). Each animal underwent sciatic nerve transection operation. After the operation, PQQ 0.5 ml (250 microg/Kg) was injected at the operation site in the PQQ group, while the same volume of normal saline was delivered in the control group. Nerve functional evaluation, electrophysiological index recording were carried out according to the experimental design. Newly generated nerve specimens were harvested 12 weeks postoperatively for morphological studies.
RESULTSIn the PQQ group there was a good nerve regeneration and the sciatic nerve function, sciatic nerve function index, electrophysiological index and morphological appearance were superior to the control group (P < 0.05).
CONCLUSIONSPQQ has a remarkable effect in enhancing nerve regeneration of transected peripheral nerve.
