Role of long non-coding RNAs in gene regulation and oncogenesis.
- Author:
Yan-feng PAN
1
;
Lei FENG
;
Xian-qiang ZHANG
;
Li-jie SONG
;
Hong-xia LIANG
;
Zhi-qin LI
;
Feng-bao TAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Transformation, Neoplastic; genetics; Gene Expression Regulation; genetics; physiology; Humans; Neoplasms; genetics; RNA, Untranslated; genetics
- From: Chinese Medical Journal 2011;124(15):2378-2383
- CountryChina
- Language:English
-
Abstract:
OBJECTIVEThis article aims to review recent studies on the biological characteristics of long non-coding RNAs (lncRNAs), transcription regulation by lncRNAs, and the results of recent studies on the mechanism of action of lncRNAs in tumor development.
DATA SOURCESThe data cited in this review were mainly obtained from the articles listed in PubMed and HighWire that were published from January 2002 to June 2010. The search terms were "long non-coding RNA", "gene regulation", and "tumor".
STUDY SELECTIONThe mechanism of lncRNAs in gene expression regulation, and tumors concerned with lncRNAs and the role of lncRNAs in oncogenesis.
RESULTSlncRNAs play an important role in transcription regulation by controlling chromatin remodeling, transcriptional control, and post-transcriptional controlling. lncRNAs are involved in many kinds of tumors and play key roles as both suppressing and promoting factors.
CONCLUSIONlncRNAs could perfectly regulate the balance of gene expression system and play important roles in oncogenic cellular transformation.
