Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China.
- Author:
Ying HAO
1
;
Bao-gang WU
;
Jin SHI
;
Yan-li CHEN
;
Zhao-qing SUN
;
Li-qiang ZHENG
;
Xin-gang ZHANG
;
Ning GENG
;
Tie-jun LI
;
Hong LI
;
Ying-xian SUN
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Female; Gene Frequency; genetics; Genetic Predisposition to Disease; genetics; Glutathione Peroxidase; genetics; Humans; Hypertension; genetics; Male; Middle Aged; Polymorphism, Single Nucleotide; genetics
- From: Chinese Medical Journal 2011;124(14):2113-2116
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDGenetic mechanisms contribute to blood pressure regulation. This study investigated whether glutathione peroxidase (GPx-3) tag single nucleotide polymorphisms (SNPs) are associated with hypertension in the rural areas of Fuxin county, Liaoning province, China.
METHODSIndigenous Fuxin Han people participated, 523 unrelated hypertensives and 547 controls were recruited. All tag SNPs of GPx-3 gene were selected. We estimated SNP allele frequency in DNA pools with pyrosequencing.
RESULTSBefore Bonferroni correction, C allele frequency for rs8177417 was significantly higher in hypertensives than those in controls (23.4% vs. 19.3%, P = 0.014); T allele frequency for rs3828599 was significantly lower in hypertensives than those in controls (35.6% vs. 40.8%, P = 0.009). However, when a Bonferroni correction for multiple testing was applied, only the polymorphisms rs3828599 of GPx-3 gene was associated with hypertension (P = 0.045, OR: 0.833, 95%CI: 0.695 - 0.998).
CONCLUSIONThe polymorphism of rs3828599 of GPx-3 gene might be associated with hypertension in rural Han Chinese from Fuxin, Liaoning.
