Colorectal cancer heterogeneity: genotype, phenotype and clinical manifestation.
- Author:
Sanjun CAI
1
;
Junjie PENG
;
Fangqi LIU
Author Information
1. Department of Colorectal Surgery, Cancer Hospital, Fudan University, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. caisanjun@gmail.com.
- Publication Type:Journal Article
- From:
Chinese Journal of Gastrointestinal Surgery
2017;20(10):1099-1103
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is the third high-incidence of malignant tumors in the world, and also a kind of tumor with good biological behavior and good efficacy. Colorectal cancer heterogeneity is a very important trait of its biological behavior, which can be reflected in many different aspects, including tumor type, pathogenesis, molecular phenotyping and time-space heterogeneity. Different pathogenesis produces different tumor phenotypes, which are generated in the process of natural evolution and intervention. Various phenotypes show the difference among different individuals of colorectal cancer, in terms of clinical characteristics, treatment response and prognosis. Understanding the heterogeneity of colorectal cancer has important clinical value for individualized treatment.
