Clinical evaluation of four cytokines in serum and prostatic fluid in chronic abacterial prostatitis.
- Author:
Shu-ping LI
1
;
Shuang-yan MENG
;
Rui LI
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Bodily Secretions; chemistry; Chronic Disease; Cytokines; metabolism; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-2; metabolism; Interleukin-4; metabolism; Interleukin-8; metabolism; Male; Middle Aged; Prostate; secretion; Prostatitis; blood; metabolism; Tumor Necrosis Factor-alpha; metabolism
- From:National Journal of Andrology 2006;12(1):25-27
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between four cytokines in serum and prostatic fluid and chronic abacterial prostatitis (CAP).
METHODSThe levels of interleukin-2 (IL-2), IL-4, IL-8, tumor necrosis factor-alpha (TNF-alpha) were detected in 86 patients with CAP [CAP I (n = 60), WBC > or = 10/HP; CAP II (n = 26, WBC < 10/HP)], and 20 healthy males as control by ELISA.
RESULTSIL-2, IL-8 and TNF-alpha in serum and prostatic fluid, and IL-4 in serum in patients with CAP I were markedly higher than those in the control, respectively (P < 0.05 or P < 0.01). No significant difference was observed in IL-4 level in prostatic fluid among CAP I, CAP II and control groups respectively (P > 0.05), and in IL-2, IL4, TNF-alpha in serum and prostatic fluid between CAP II group and the control (P > 0.05). IL-8 was correlated with WBC number in prostatic fluid (r = 0.62, P < 0.05).
CONCLUSIONIL-2, IL-8, TNF-alpha may play roles in the process of pathogenesis of CAP, and they have applicable value in the diagnosis and typing of CAP.
