Expression of sexual hormon receptors in prostatic cancer tissues.
- Author:
Tao DING
1
;
Wen-jun CHE
;
Tong-ju CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Follow-Up Studies; Humans; Immunohistochemistry; Male; Middle Aged; Prostatic Hyperplasia; metabolism; Prostatic Neoplasms; metabolism; Receptors, Androgen; biosynthesis; Receptors, Estrogen; biosynthesis; Receptors, Progesterone; biosynthesis
- From:National Journal of Andrology 2006;12(1):50-56
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between the androgen receptor (AR), oestrogen receptor( ER) and progesterone receptor (PR) by assaying the distributions of these three receptors in the both benign prostate hyperplasia (BPH) and prostatic cancer (PCa) tissues, then to explore the difference of the effects of hormonal treatment between the AR positive and AR negative in PCa patients.
METHODSTo observe AR, PR and ER expressions in 30 cases of BPH and 32 cases of PCa tissues by DAKO Envision methods.
RESULTSThere were 22 AR positive, 10 ER positive and 6 PR positive cases in 30 BPH patients, and there were 18 AR positive, 14 ER positive and 2 PR positive in 32 PCa patients. There was no significant difference between the two groups. The survival time was 6.41 and 4.28 years for the AR positive and AR negative respectively in 30 PCa patients. The AR positive patients lived longer than the AR negative (P < 0.05).
CONCLUSIONThese three receptors cant result in PCa and the effects of hormonal treatment on AR negative PCa patients is not certain.
