Expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor in prostate cancer and its significance.
- Author:
Liang WANG
1
;
Zhao-jie CHEN
;
Qing-tang WANG
;
Wen-feng CAO
;
Yi JIAN
;
Sheng-xian WANG
;
Bing-hong ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; biosynthesis; Immunohistochemistry; Male; Middle Aged; Prostatic Hyperplasia; metabolism; Prostatic Intraepithelial Neoplasia; blood supply; metabolism; Prostatic Neoplasms; blood supply; metabolism; Vascular Endothelial Growth Factor A; biosynthesis
- From:National Journal of Andrology 2006;12(1):57-59
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and vascular endothelial growth factor (VEGF) in prostate cancer (PCa) and its biological significance.
METHODSSpecimens from 75 patients with PCa (32 cases), benign prostatic hyperplasia (BPH, 16 cases), high-grade prostate intraepithelial neoplasia (PIN, 15 cases) and normal prostate (NP, 12 cases) were comprised in the study. The PCa was divided into high Gleason score group (Gleason score > or = 7) and low Gleason score group (Gleason score < 7). Immunohistochemistry was performed with antibodies against HIF-1 alpha, VEGF and CD34. Microvessel density (MVD) was analyzed by staining with antibodies to CD34.
RESULTSThe positive rates of HIF-1alpha were significantly higher in PCa (62.5%) and PIN (60.0%) than those in BPH (6.3%) and NP(0) (P < 0.05), respectively. The positive rates of VEGF were significantly higher in PCa (78.1%) and PIN (73.3%) than those in BPH (18.7%) and NP (8.3%) (P < 0.05), respectively. A higher concentration of MVD was observed in PCa (66.9 +/- 18.0) compared with those in BPH (28.3 +/- 6.9) and NP (15.3 +/- 2.9) (P < 0.05). MVD and the positive rates of HIF-1alpha and VEGF were significantly higher in high Gleason score group than those in low Gleason score group.
CONCLUSIONThe results suggest that the overexpression of HIF-1alpha and VEGF are closely related to PCa, and the son score group. up-regulation of HIF-1alpha and VEGF are early events in PCa.
