Impacts of denervation on the morphology and expression of neuronal nitric oxide synthase of prostate of adolescent rats.
- Author:
Mao-Hua LUO
1
;
Shi-Wen LI
;
Xin-Min ZHENG
;
Li-Quan HU
;
Yi LUO
;
Hang ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis; Denervation; In Situ Nick-End Labeling; Male; Nitric Oxide Synthase Type I; biosynthesis; Prostate; cytology; innervation; metabolism; Random Allocation; Rats; Rats, Sprague-Dawley; Sexual Maturation
- From: National Journal of Andrology 2006;12(2):112-119
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the impacts of denervation on the morphology and the expression of neuronal nitric oxide synthase (nNOS) of prostate of the adolescent rats.
METHODSAdolescent male SD rats were randomly divided into group A and group B. The right pelvic ganglion denervation was performed in group B with the help of surgical microscope, and group A received a sham operation. Five weeks later, the ventral prostates were obtained for morphologic observation, apoptosis detection and the evaluation of nNOS expression.
RESULTSA 30.8% reduction of right ventral prostate (RVP) fresh weight was found in group B. After denervation, histological features showed an overall decrease in the numbers of cells and cell height, and apoptosis indexes (AI) was significantly higher than that in group A (P <0.01), while the expression of nNOS decreased apparently (P < 0.01).
CONCLUSIONThe study indicates that denervation can cause apoptosis of the prostatic, and affect the prostate growth of the adolescent rat. During this process, nNOS plays an important role in the regulation of apoptosis.
