Correlation between integrin subunits alpha5 and beta1 expressions in prostate cancer and its clinical implication.
- Author:
Hai-Jiao CHEN
1
;
Hao WANG
;
Li ZHANG
;
Yong-Kang ZHANG
;
Guo-Min WANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Animals; Humans; Integrin alpha5; biosynthesis; Integrin alpha5beta1; biosynthesis; Male; Mice; Middle Aged; Neoplasm Staging; Prostatic Hyperplasia; metabolism; Prostatic Neoplasms; metabolism; pathology
- From: National Journal of Andrology 2006;12(2):148-150
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the correlation between the expression of integrin subunits alpha5 and beta1 in prostate cancer (PCa) and its clinicopathological data including tumor grade and clinical stage.
METHODSExpressions of integrin subunits alpha5 and beta1 were examined in 30 cases of PCa and 30 cases of normal prostatic tissues by immunohistochemical assay.
RESULTSExpressions of integrin subunits alpha5 and beta1 in PCa were lower than those in normal prostatic tissues (P <0.05) respectively.
CONCLUSIONCompared with normal prostatic tissues, expressions of integrin subunits alpha5 and beta1 in PCa were rather weaker or even faded. Expressions of integrin subunits alpha5 and beta1 revealed an positive correlation with tumor's Gleason grade and negative with clinical TNM stage. The results indicate that integrin subunits alpha5 and beta1 have potential values in the diagnosis and are predictable indices in the proliferation of PCa.
